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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4G2
All Species:
13.64
Human Site:
T521
Identified Species:
42.86
UniProt:
P78344
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78344
NP_001409.1
907
102362
T521
T
P
Q
L
G
L
K
T
N
P
P
L
I
Q
E
Chimpanzee
Pan troglodytes
XP_001170632
1033
115739
T647
T
P
Q
L
G
L
K
T
N
P
P
L
I
Q
E
Rhesus Macaque
Macaca mulatta
XP_001093873
1176
131101
T790
T
P
Q
L
G
L
K
T
N
P
P
L
I
Q
E
Dog
Lupus familis
XP_851579
701
79569
L372
M
R
A
P
K
H
F
L
P
E
M
L
S
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q62448
906
102087
T520
T
P
Q
L
G
L
K
T
N
P
P
L
I
Q
E
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515837
496
55369
E167
Q
L
C
L
R
L
A
E
D
A
P
N
F
D
G
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_394628
920
105173
K523
L
S
P
A
I
V
I
K
Q
G
P
V
D
K
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782944
923
103756
G536
S
A
A
G
S
L
G
G
G
T
G
G
A
P
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.8
76.9
77.1
N.A.
99.1
N.A.
N.A.
51
N.A.
N.A.
N.A.
N.A.
N.A.
37.9
N.A.
28.9
Protein Similarity:
100
87.8
77.1
77.2
N.A.
99.7
N.A.
N.A.
51.8
N.A.
N.A.
N.A.
N.A.
N.A.
56.7
N.A.
48
P-Site Identity:
100
100
100
6.6
N.A.
100
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
100
13.3
N.A.
100
N.A.
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
25
13
0
0
13
0
0
13
0
0
13
0
13
% A
% Cys:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
13
0
0
0
13
13
0
% D
% Glu:
0
0
0
0
0
0
0
13
0
13
0
0
0
0
50
% E
% Phe:
0
0
0
0
0
0
13
0
0
0
0
0
13
0
0
% F
% Gly:
0
0
0
13
50
0
13
13
13
13
13
13
0
0
13
% G
% His:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
13
0
13
0
0
0
0
0
50
0
0
% I
% Lys:
0
0
0
0
13
0
50
13
0
0
0
0
0
25
0
% K
% Leu:
13
13
0
63
0
75
0
13
0
0
0
63
0
0
0
% L
% Met:
13
0
0
0
0
0
0
0
0
0
13
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
50
0
0
13
0
0
0
% N
% Pro:
0
50
13
13
0
0
0
0
13
50
75
0
0
13
0
% P
% Gln:
13
0
50
0
0
0
0
0
13
0
0
0
0
50
0
% Q
% Arg:
0
13
0
0
13
0
0
0
0
0
0
0
0
0
13
% R
% Ser:
13
13
0
0
13
0
0
0
0
0
0
0
13
0
0
% S
% Thr:
50
0
0
0
0
0
0
50
0
13
0
0
0
0
0
% T
% Val:
0
0
0
0
0
13
0
0
0
0
0
13
0
0
13
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _